Statistical Methods for Drug Discovery

Kuhn M, Yates P, Hyde C (2016). “Statistical Methods for Drug Discovery.” In Nonclinical Statistics for Pharmaceutical and Biotechnology Industries, volume 1, 53-82. Springer.

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• DOI: 10.1007/978-3-319-23558-5_4

Abstract

This chapter is a broad overview of the drug discovery process and areas where statistical input can have a key impact. The focus is primarily in a few key areas: target discovery, compound screening/optimization, and the characterization of important properties. Special attention is paid to working with assay data and phenotypic screens. A discussion of important skills for a nonclinical statistician supporting drug discovery concludes the chapter.